Diagnosed at 38 a few days before Christmas 2011 with my then 2 year old daughter on my lap, I was told I had Chronic Lymphocytic Leukaemia (CLL), an incurable disease where the average patient with my prognostic markers could expect to live for 5 years. The average patient, however, was a 70 year old man. A year later I became so sick I required treatment and had 3 cycles of a chemotherapy known as FCR. My remission only lasted 6 months and it looked very much as if I was going to have to have an allogeneic transplant using stem cells from a donor to save my life. This is a difficult treatment and, while, if it works the benefits are long term control of the disease, the risks are high and mortality rates and quality of life issues made this something I wasn’t ready for. I began this blog in 2015 after a global search for an experimental treatment resulted in me moving to London to start a clinical trial at Barts Hospital of two drugs which have not been used in combination before – one of these is ABT-199, now known as Venetoclax, which was ironically invented in my adopted hometown of Melbourne. 5 years later in September 2020 I’m reactivating it again to follow my path through another cutting edge clinical trial which I’m hoping will finally cure me. That is called CAR-T and I will officially become a genetically modified human being right here at my local hospital the Peter MacCallum Cancer Centre. I feel very privileged and grateful to be on this trial and this blog is designed to help other patients who may choose this path down the track. It will be a bit technical for my non amateur haematologist friends but the CLLers it’s aimed at will understand.